microglycodb_gene_00124

Gene Number Cj1328
Gene Name neuC2    
UniProt ID Q0P8T0
NOTES - phase variation etc Putative UDP-N-acetylglucosamine 2-epimerase
Sugar/modification added
Reviewed true
Biosynthesis Flagellin O-glycan biosynthesis
Organism Campylobacter jejuni
functions
sequence
publications
reaction
Data not found

 Involved in biosynthesis of legionaminic acid (5,7-diamino-3,5,7,9-tetradeoxy-D-glycero-D-galacto-non-2-ulosonic acid)(Leg), a sialic acid-like derivative that is incorporated into flagellin via O-linkage to Ser/Thr. Catalyzes the conversion of GDP-N,N'-diacetylbacillosamine (Bac2Ac4Ac) into 2,4-diacetamido-2,4,6-trideoxymannose and GDP. It can also use UDP-N,N'-diacetylbacillosamine however it generates small quantities of 2,4-diacetamido-2,4,6-trideoxymannose.

        10         20         30         40         50

MSKRKICIVS ATRAEWYLLR NLCHEIQNDK DLSLQIIATG AHLSPEFGLT 

        60         70         80         90        100

YKEIEKEFKI TKKIPILLAN DDKISLCKSM SLAFSAFSDA FEDLKPDMVV 

       110        120        130        140        150

ILGDRYEMLS VASVCLLMHI PLVHLCGGEL TLGAIDDSIR HSISKMSHLH 

       160        170        180        190        200

FVSHEIYKKR LLQLGEEEKR VFNIGSLAST IIKNMNFLNK KDLEKALEMK 

       210        220        230        240        250

LDKELYLITY HPLTLNVKNT QKEIKTLLKK LDTLKNASLI FTKANADENG 

       260        270        280        290        300

LLINEILQNY CQKNSHKAKL FDNLGSQKYL SLMKIAKAMI GNSSSGISES 

       310        320        330        340        350

PFFKTPCINI GDRQKGRLRT QNIIDSEIND LDQAFEKLES KEFKQNLKNF 

       360        370        380        390

KNPYDNGKNP NKIIKTCLKN VNLDTILHKN FIDL




1. The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences.

PubMed: 10688204

doi:10.1038/35001088


2. The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors.

PubMed: 19282391

doi:10.1093/glycob/cwp039