MicroGlycoDB

Gene Name	CKF44_05583
Predicted domain	Glucosylceramide synthase
Putative function	GCS1
NCBI Protein ID	AUB29236.1
Protein Name
CAZy Family	GT21
Conserved Protein Domain Family	133012
Organism	Cryptococcus neoformans

        10         20         30         40         50

MSDSGTLSLI GGIVFLVLWV VVWSICLLGW RTARIRYAHP NIPSRLSKLP

        60         70         80         90        100

VSSAPGVTII RPLCGLDQNL YNTLESVMKL DYPKFEVIFA VQDEKDEALP

       110        120        130        140        150

VVNMVMEKYP EVEAKVIIDS RKVGVNPKVN NLMTPFQEAK YDLLWILDST

       160        170        180        190        200

CSVLPGTLGR SVEAFFSNTS STASPYDPES SPLLSISDDV RKPPIAGEVG

       210        220        230        240        250

LVHQVPIAVC YQKTWGSLIE QAYLNTTHAK MYLAINATSI DSCVVGKSCM

       260        270        280        290        300

YSRDNISHLT TPSPSLRSLP DPPSGLAGFG PFLAEDNMIG LSLWHELKLK

       310        320        330        340        350

HAMTSDVVLD FIGSLSVRDY INRRVRWIRV RKKMTLAATL LEPLTESIIS

       360        370        380        390        400

GLYGAWAISR LLGGNILPLF LLHMAAWISV DISTKRALET NIKGIGPPES

       410        420        430        440        450

KVTFLMAWAA RECLALPIWM LAMTSSEVVW RGQKYKIIAS GEAIRLGDRN

1. Glucosylceramide synthase is an essential regulator of pathogenicity of Cryptococcus neoformans.

doi:10.1172/jci27890